Hello,
I use :
Joomla 2.5.27
ARTIO JoomSEF 4.5.4
Hotspots Professional 4.2.1

when I put YES, at the Joomla Global Configuration, under SEO Settings -
Joomla Search Engine Friendly URLs, the following message appears:
Fatal error: Call to a member function get() on a non-object in /home/motorcbt/http://www.motorhome-travels.com/components/com_hotspots/views/hotspots/view.html.php on line 77

At Joomla Search Engine Friendly URLs put on NO, it works just fine.
Thanks for your support.
Herbert